This was similar to proteins observed to co-aggregate (co-aggregators) with plaques (median Δ: 6.0x, p = 4.5•10− 8) and neurofibrillary tangles (median Δ: 5.2x, p = 1.3•10− 13) in AD, and TDP-43 (median Δ: 2.1x, p = 1.8•10− 3) in ALS, respectively (Fig. 2b, Additional file 1: Dataset S7). This evidence concerns the gene TARDBP and Alzheimer disease.