Germline mosaic alterations of the PTEN locus, associated in trans with inherited PTEN variants, have also been reported in a distinct clinical presentation corresponding to segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome due to PTEN nullizygosity [12, 13] and for review see ref. [14]. This evidence concerns the gene PTEN and lipomatosis.