Given that MORC2 is upregulated in multiple types of human cancer [46] and contributes to cancer growth and progression [22–25] as well as cellular response to ionizing radiation [13] and chemotherapeutic drugs [25], these findings broaden our understanding of the functional roles of MORC2 in DDR and highlight MORC2 as a potential target for cancer treatment. The gene discussed is MORC2; the disease is cancer.