These include epigenetic downregulation of GAS7, OSR1, SELENBP1, TGFBR3, and ZBTB16, earlier found associated with OSCC/HNSCC; epigenetic upregulation of TRPM2 and LCK (a proto-oncogene), earlier observed overexpressed in patients with OSCC or oral lichen planus (oral pre-cancer); altered expression of epigenetically downregulated (CDON, ID4, ZSCAN18, CPEB1, and NUPR1) or epigenetically upregulated (SULF1 and SEMA3C) genes earlier associated with several cancer types. This evidence concerns the gene NUPR1 and head and neck squamous cell carcinoma.