These include epigenetic downregulation of GAS7, OSR1, SELENBP1, TGFBR3, and ZBTB16, earlier found associated with OSCC/HNSCC; epigenetic upregulation of TRPM2 and LCK (a proto-oncogene), earlier observed overexpressed in patients with OSCC or oral lichen planus (oral pre-cancer); altered expression of epigenetically downregulated (CDON, ID4, ZSCAN18, CPEB1, and NUPR1) or epigenetically upregulated (SULF1 and SEMA3C) genes earlier associated with several cancer types. The gene discussed is CDON; the disease is head and neck squamous cell carcinoma.