ERBB2 and metastatic neoplasm: Lapatinib, a reversible inhibitor of EGFR and HER2 RTKs, is active in the first and subsequent lines of treatment of patients with HER2+ metastatic disease and has received US Food and Drug Administration (FDA) approval when combined with capecitabine in patients with progressive disease after anthracycline, a taxane, and trastuzumab [10].