GRHL1 and cardiovascular disorder: Other CBCT-associated genes were ACOT7, implicated in the pathophysiology of type 2 diabetes [30] and atherosclerosis [31]; GRHL1, encoding a transcription factor involved in epithelial development and linked to several types of cancer, cardiovascular diseases, and type 1 diabetes; and TOM1L2, linked to body mass and type 2 diabetes in GWAS [32] (Table 2).