HIF1A and pituitary gland adenoma: In addition, hypermethylation of ANKDD1A in glioblastoma has been reported; this gene interacts with FIH1 and decreases HIF1-α stability to inhibit cell autophagy in a hypoxic microenvironment [36, 37], but its function in pituitary adenoma or the significance of promoter methylation is still unclear.