ANGPT2 and idiopathic pulmonary fibrosis: While Attia et al. did not observe a difference in ANG-2 levels in bronchoalveolar lavage fluid of patients with ARDS versus healthy controls, the research group of Ando et al. did demonstrate a significant increase of ANG-2 in patients with ARDS versus patients with idiopathic pulmonary fibrosis [57, 61].