Whereas HEYL mRNA expression was undetectable in control vector-transduced CRC cultures, HEYL mRNA was strongly overexpressed in HEYL-transduced cultures (M1 = 650-fold; NM1 = 22-fold higher compared to HEK-239 T untransduced control) further validating successful lentiviral gene transfer (Fig. 2d). This evidence concerns the gene HEYL and colorectal carcinoma.