HEYL and colorectal carcinoma: While our analysis of publicly available CRC datasets suggested an association of high HEYL RNA levels with advanced CRC and CRC metastasis, functional analysis in xenotransplantation models of patient-derived cells pointed towards a metastasis-inhibiting role of HEYL with a decrease in the metastasis formation capacity of patient-derived CRC cells in the sub-renal capsular xenotransplantation model after HEYL overexpression.