Functional characterization and how the down-regulation of miRNAs could affect tumourigenesis in pancreas has already been worked out for many of these repressed miRNAs as we find miR-126-3p targeting ADAM9, KRAS and CRK oncogene, while miR-26a suppressing cycling E2 mediated progression of cell cycle in pancreatic cancer. The gene discussed is CRK; the disease is familial pancreatic carcinoma.