A number of the most significant activations, such as cytokine–cytokine receptor pathways including cancer regulating chemokines CXCL10, CXCL11, the T-cell trafficking chemokine CXCR3 [23,24] and the toll-like receptor signaling pathways TLR3/TlR4 are drivers of well accepted anti-tumor or pro-immune response groups. This evidence concerns the gene TLR4 and cancer.