The strongest associations found were: T1/FLAIR ratio with down-regulation of AMPK and acute myeloid leukemia signaling; MRI necrosis with up-regulation of PI3K/AKT/mTOR signaling and apoptosis, although correlated with down-regulation of AMPK and protein kinase A signaling; edema with increased NGF signaling and G1/S checkpoint regulation; the presence of cysts with decreased PI3K/AKT and phospholipase C signaling; localization of tumor to the parietal lobe with up-regulated p53 signaling activity and with down-regulated IL-8 signaling. The gene discussed is AKT1; the disease is acute myeloid leukemia.