Mutations in Crx can cause Leber congenital amaurosis (LCA), cone-rod dystrophy (CRD), and Retinitis pigmentosa (RP), while Nrl and Nr2e3 mutations can cause RP and enhanced S-cone syndrome [92,93,94,95,96,97,98]. The gene discussed is NR2E3; the disease is Leber congenital amaurosis.