The four CRB1-LCA-like models had both alleles of Crb2 disrupted in either retinal progenitor cells (ΔRPC), immature photoreceptors (ΔimPRC), or Müller glial cells (ΔMG) on genetic backgrounds with either reduced levels of (Crb1KO/WTCrb2ΔRPC) or complete knockout of Crb1 (Crb1KOCrb2ΔRPC, Crb1KOCrb2ΔimPRC, Crb1KOCrb2ΔMG). The gene discussed is CRB2; the disease is Leber congenital amaurosis.