Molecular genetic testing of additional genes, including STAP1, CYP7A1, LIPA, ABCG5, ABCG8, and PNPLA5, may be useful for the early diagnosis of polygenic FH, i.e., patients with clinically confirmed (definite) FH, but without the major mutations associated with FH (to be distinguished from nonfamilial multifactorial hypercholesterolemia). Here, ABCG5 is linked to familial hyperaldosteronism.