ABCG5 and familial hypercholesterolemia: In Spanish patients with hypercholesterolemia, Asn578Ser (rs146534033), Gly288Cys (rs139264483), Arg198Glu (rs141828689), Gly269Arg (rs552803459), and Asn296Ser (rs552803459) in ABCG5 and Gly512Arg (rs376069170) in the ABCG8 gene have been detected [92].