ABCG5 and familial hyperaldosteronism: Among patients with FH, carriers of the Gln604Glu allele (rs6720173) of ABCG5 are reported to have a lower concentration of triglycerides and very-low-density lipoprotein, whereas the presence of intron variant rs4131229A>G, rs4148189C>T, or rs4289236G>A of this gene has been found to be associated with higher levels of total cholesterol and triglycerides as well as a lower level of HDL-C only in smokers [91].