Molecular genetic testing of additional genes, including STAP1, CYP7A1, LIPA, ABCG5, ABCG8, and PNPLA5, may be useful for the early diagnosis of polygenic FH, i.e., patients with clinically confirmed (definite) FH, but without the major mutations associated with FH (to be distinguished from nonfamilial multifactorial hypercholesterolemia). This evidence concerns the gene STAP1 and familial hyperaldosteronism.