Molecular genetic testing of additional genes, including STAP1, CYP7A1, LIPA, ABCG5, ABCG8, and PNPLA5, may be useful for the early diagnosis of polygenic FH, i.e., patients with clinically confirmed (definite) FH, but without the major mutations associated with FH (to be distinguished from nonfamilial multifactorial hypercholesterolemia). The gene discussed is CYP7A1; the disease is familial hyperaldosteronism.