EPAS1 and non-small cell lung carcinoma: Furthermore, both Hif-1α and Hif-2α are frequently overexpressed in NSCLC correlating, in some cases, with poor prognosis [60,61] and Hif-1α expression is associated with resistance to cancer therapy, including EGFR (epidermal growth factor receptor 1) inhibitors in NSCLC [46].