To further investigate the critical role of PTX3 in AMD pathogenesis, such as oxidative stress, RPE cell death, and AMD-associated gene expression, we examined mRNA levels of antioxidative enzymes in hPTX3 shRNA expressing ARPE-19 cells compared with control shRNA expressing ARPE-19 cells in response to NaIO3. The gene discussed is PTX3; the disease is age-related macular degeneration.