In glioma cells, ER stress triggered by different drug treatments increases p-eIF2α in conjunction with elevated expression of other ER stress transducers (i.e. p-ERK, ATF6, p-IRE-1, GRP78, CHOP, XBP-1) enhancing glioma cell death [109,110,111]. The gene discussed is HSPA5; the disease is central nervous system cancer.