AMPK activation by flavones such as Hispidulin and Wogonin as well as other drugs already under clinical investigation like Metformin and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) suppresses the mTOR pathway and decreases p-4E-BP1 causing apoptosis and cell cycle arrest in GBM cell lines [153,154,155,156,157,158,159,160]. The gene discussed is EIF4EBP1; the disease is glioblastoma.