In addition, N1,N11-diethylnorspermine (DENSP) which targets the polyamine pathway, has been shown to decrease the expression of mediators of mTOR pathway (i.e., Akt, p-Akt, mTOR, p-mTOR, p-70S6K1, p-p70S6K1, 4E-BP, and p-4E-BP) in GBM cells and to reduce mTOR dependent protein synthesis [140]. This evidence concerns the gene AKT1 and glioblastoma.