Eltrombopag, an orally active thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity, and arotinolol, a medication in the class of mixed α/β blockers used in the treatment of high blood pressure and essential tremor were the most potent compounds of the series identified in this study against Mtb in macrophages and axenic culture, respectively. This evidence concerns the gene MPL and hypertensive disorder.