TP53 and hepatocellular carcinoma: Furthermore, along with in normal cells, the exogenous expression of both Δ40p53 and wild-type p53 in human hepatocellular carcinoma cell lines reduced cell growth and induced senescence by increasing the expression of p21Waf1/Cip1 and IL-8 to stabilize full-length p53 [83] (Figure 3).