TP53 and neoplasm: These drugs induce apoptosis by upregulating several pro-apoptotic p53 target genes, such as PUMA (p53 upregulated modulator of apoptosis), NOXA (Laten for damage), BAX (Bcl-2-associated X protein), and BAK (BCL2-antagonist/killer 1), which are all critical for tumor suppression [41].