Although comparable numbers of CD19+CD24hiCD38hi Bregs were observed between healthy individuals and SLE patients, CD19+CD24hiCD38hi Bregs in lupus patients failed to suppress T helper cell differentiation and proinflammatory cytokine secretion, which might be due to the dampened IL-10 secretion and impaired CD40 signal [125]. This evidence concerns the gene CD40 and systemic lupus erythematosus.