TP53 and malignant colon neoplasm: In a similar way, exosomes derived from TP53-deficient colon cancer cells accelerate co-cultured fibroblast proliferation by the transfer of several microRNAs (miR-1249-5p, miR-6737-5p, and miR-6819-5p) that suppress TP53 expression in fibroblasts [42].