Moreover, microRNA 200 contained in exosomes from colorectal cancer cells downregulates the expression of epithelial to mesenchymal transition-regulating transcription factors such as Zinc Finger E-box Binding Homeobox 2 (ZEB2), Snail Family Transcriptional Repressor 1 (SNAI), and Snail Family Transcriptional Repressor 2 SLUG in endothelial and lymphatic cells that modulate the resistance of endothelial barriers that resemble gates for tumor transmigration [56,57]. This evidence concerns the gene ZEB2 and colorectal cancer.