Further, it was shown that this phosphorylation of GIV/Girdin is essential in AMPK-dependent TJ formation and apicobasal epithelial cell polarity establishment, and that an oncogenic mutant of GIV which cannot be phosphorylated by AMPK increases tumor cell growth through the defects in establishing apicobasal cell polarity [95]. This evidence concerns the gene CCDC88A and neoplasm.