MAPT and Alzheimer disease: The pathological features of AD include the formation of intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated Tau, and the extracellular deposition of amyloid-β (Aβ) aggregates derived from the sequential processing of the β amyloid precursor protein (βAPP) by β- and γ-secretases [2].