We observed a significant increase of the expressions of ATF4 (Figure 2A,E), GRP78 (Figure 2A,F), and calreticulin (CRT) (Figure 2A,H) in AD brains as compared to controls, while the ubiquitous SERCA2b isoform (Figure 2A,B), p-eIF2α (Figure 2A,C), and GRP94 (Figure 2A,G) expressions remained unchanged. Here, HSPA5 is linked to Alzheimer disease.