In a study by Ippagunta et al. the authors investigated the role of different components of the NLRP3 inflammasome and showed that NLRP3(−/−) and caspase-1(−/−) mice were predisposed to collagen-induced arthritis while ASC(−/−) mice were protected from arthritis [89]. This evidence concerns the gene CASP1 and arthritic joint disease.