We selected 30 samples for omics analysis using microarray (14 samples) and next-generation sequencing (NGS) (16 samples) to study the dynamic changes of pathways from normal diet (NOR), overfeeding (DIO) using diet-induced obesity, and high-fat-diet (FAT) treatment in four fish types: wild-type (WT), overexpression of hepatitis B virus X antigen (HBx) with p53 mutation (HBx(p53-)), overexpression of Src with p53 mutation (Src(p53-)), and overexpression of both HBx and Src with p53 mutation (HBx,Src(p53-)). Here, SRC is linked to obesity due to melanocortin 4 receptor deficiency.