Additionally, similar findings were seen in Ba/F3 mouse progenitor cell lines transfected with both the FLT3-ITD and FLT3-TKD (D835Y) constructs compared to parental cells, as well as in primary AML cell lines with the FLT3-ITD mutation (MV4-11, MOLM-13) compared to a wild-type FLT3 cell line REH. The gene discussed is FLT3; the disease is acute myeloid leukemia.