BCR-ABL-driven chronic myeloid leukaemia (CML) and Janus kinase 2 (JAK2) V617F-mutated myeloproliferative neoplasm (MPN) cell lines showed similar results, suggesting a role for NOX-derived ROS in myeloid neoplasms driven by oncogenic tyrosine kinases more broadly [76]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.