PP2A inhibition is essential for leukaemias driven by oncogenic mutant c-KIT [93] and FLT3 [94], with the PP2A-C catalytic subunit (PPP2CA) oxidised at cysteine residues, Cys266/269, contributing to the loss of the phosphatase activity under oxidative stress [95]. The gene discussed is PPP2CA; the disease is leukemia.