Another inherited neurodegenerative disease involving protein aggregation includes frontotemporal dementia (FTD), which is caused by mutations in either the microtubule-associated protein Tau (MAPT:FTDP - 17MAPT) or the progranulin (PGRN:FTDP - 17PGRN) genes. This evidence concerns the gene MAPT and neurodegenerative disease.