Here, we provide evidence that links FOXD1 with Gal-3 in lung cancer, in which FOXD1 enhanced Gal-3 expression (Figure 2); subsequently, Gal-3-mediated ITGβ1/ETS-1 signaling contributed to further increase FOXD1 expression (Figure 4). The gene discussed is ITGB1; the disease is lung carcinoma.