Among the genes, high expression of 10 genes (STAMBP, TIMP4, TMEM14C, CANX, SUV420H1, HSP90B1, PDIA3, MTHFD2, BCAT1, and SLC22A15) was associated with poor prognosis (5-year overall survival rate: p < 0.05) in patients with HNSCC (Table 2 and Figure 3). The gene discussed is KMT5B; the disease is head and neck squamous cell carcinoma.