We found that low dietary ORAC was associated with a significant increase in CRC in the group with elevated IL-6 levels (total ORAC OR Q4 vs. Q1, 95% CI = 4.34, 3.12–6.02, p < 0.001; total phenolics = 4.61, 3.33–6.39, p < 0.001). Here, IL6 is linked to colorectal carcinoma.