According to the subgroups of dietary ORAC, we found that a high level of IL-6 was strongly associated with an increased the risk of CRC in the lower intake of H-ORAC, L-ORAC, T-ORAC, and TPs groups in the comparison between the highest and lowest quartiles as follows: H-ORAC (OR Q4 vs. Q1, 95% CI = 4.26, 3.07–5.91, p < 0.001); L-ORAC (OR Q4 vs. Q1, 95% CI = 4.70, 3.38–6.52, p < 0.001); T-ORAC (OR Q4 vs. Q1, 95% CI = 4.34, 3.12–6.02, p < 0.001); and TPs (OR Q4 vs. Q1, 95% CI = 4.61, 3.33–6.39, p < 0.001), after adjusting for the aforementioned confounding variables. The gene discussed is IL6; the disease is colorectal carcinoma.