CASP3 and rheumatoid arthritis: In 2017, Yao et al. reported that three natural compounds including Tamaractam (39), Cis-N-feruloyl-3-O-methylaids (40), and Trans-N-feruloyl-3-O-methylaids (41) isolated from Tamarix ramosissima showed in vitro pro-apoptotic effects on RA-FLS and up-regulated caspase-3 and-7.