BBC3 and cancer: PUMA is a key protein that mediates p53-dependent and p53-independent apoptosis, and current investigations also found that natural monomers, such as Resveratrol and Gallic acid, can increase the expressions of p53 and PUMA to promote apoptosis of various cancer cells or fibroblasts [51,71,72]; thus we speculated that up-regulation of PUMA is also a possible target for herbal medicines and its constituents for treating RA.