Brucine (32) is an important alkaloid of Strychni Semen, and is reported by Tang that Brucine (0.125–2 mg/mL) has potential inhibitory effect on proliferation of TNF-αstimulated RA-FLS cells via down-regulating JNK MAPK and p-JNK MAPK [113]. The gene discussed is MAPK8; the disease is rheumatoid arthritis.