Another work in 2011 by Wang reported that Berberine (6) (5–75 μM) can induce apoptosis in RA-FLS by increasing Caspase-3, -9, Bax and PARP, whereas decreasing MCMP (Δψm), Bcl-2 and Bcl-xL [60]. This evidence concerns the gene CASP3 and rheumatoid arthritis.