In addition, Yang studied the effect of Anacardic acid (35) on RA, and found that anacardic acid has good therapeutic effect on symptoms of CIA rats, and the Anacardic acid (5, 30, and 60 μM) can induce apoptosis of the RA-FLS, and the possible mechanism is closely related to the PI3K/Akt signal pathway [133]. Here, AKT1 is linked to rheumatoid arthritis.