An investigation in 2011 by Dai et al. studied the anti-RA effects of seaweed polysaccharide (SWPD) in vitro on RA-FLS, and the results revealed SWPD (15, 20, 25 mg/mL) has significantly anti-proliferative activity on RA-FLS via inducing mitochondrial apoptosis pathway in RA-FLS through up-regulating Bax and Caspase-3 whereas down-regulating Bcl-2 [53]. Here, CASP3 is linked to rheumatoid arthritis.