Another work in 2011 by Wang reported that Berberine (6) (5–75 μM) can induce apoptosis in RA-FLS by increasing Caspase-3, -9, Bax and PARP, whereas decreasing MCMP (Δψm), Bcl-2 and Bcl-xL [60]. The gene discussed is BCL2; the disease is rheumatoid arthritis.