CASP3 and rheumatoid arthritis: Moreover, a natural polyphenolic acid named Gallic acid (9) was investigated by Yoon et al. in 2013, and Yoon et al. found that this Gallic acid (0.1, 1 μM) could induce apoptosis in RA-FLS via regulation of Bcl-2, Bax, p53 and Caspase-3 [63].