In 2009, it is reported by Li et al. that besides mitochondrial dependent apoptosis, the anti-proliferative effects of Scopoletin (4) on RA-FLS also closely related to NF-κB pathway via regulation of Bax, IκBα, p-IKK and p-IκBα [57]. Here, NFKB1 is linked to rheumatoid arthritis.