Afterwards, Liu et al. in 2016 recorded another natural coumarin constituent named Daphnetin (3) (40 μg/mL) extracted from Daphne odora could induce apoptosis in RA-FLS of CIA rats, and after Daphnetin treatment, the Caspase-3, -8, -9, Bax, Bid, Cyt-C were significantly up-regulated whereas the Bcl-2 were down-regulated [51]. Here, CASP3 is linked to rheumatoid arthritis.