Heiguteng-Zuifenghuoluo Capsule (HGTZFC) is a Chinese patent medicine used for treating RA, Liu et al. reported that HGTZFC (0.315 g/kg) could down-regulate the HIF-α, p-PI3K, p-Akt, and Bcl-2, whereas up-regulate Bax in synovial tissue of CIA rats [130]. This evidence concerns the gene AKT1 and rheumatoid arthritis.