CASP3 and rheumatoid arthritis: In the study of Shang et al. (2016), it was found that Oridonin (14) (5, 10, 25, 40 μM) can induce the apoptosis in RA-FLS, regulate the mRNA expressions of Bax and Bcl-2, reduce cells’ MCMP, promote the outflow of Cyt-C, and activate Caspase-3 [68].