CASP3 and rheumatoid arthritis: Additionally, another report by Jie et al. studied the effect of Tanshinone IIA (13), and found that this compound (2.5–20 μM) could induce apoptosis in RA-FLS by mitochondrial pathway via up-regulating Bax, cytosolic Cyto C, Apaf-1, Caspase-3, -9 whereas down-regulating Bcl-2 [67].