Besides, it is reported that Cryptotanshinone (17) (5 μM), a fat soluble anthraquinone derivative isolated from the Salvia miltiorrhiza, could induce the apoptosis in MH7A cells and RA-LFS cells via reactive oxygen species (ROS) induced apoptosis by regulation of Bcl-2, Bad, cleaved-Caspase-3 and PARP [75]. The gene discussed is CASP3; the disease is rheumatoid arthritis.