CASP3 and rheumatoid arthritis: Another work in 2013 by Xu suggested that Celastrol (10) (1, 2, 5 μM) also induced apoptosis in RA-FLS via increasing Caspase-3, -9, PARP, Fas and Bax, whereas decreasing Bcl-2 and MCMP (Δψm) [64].