BCL2 and arthritic joint disease: In 2018, Gao and Lu studied effect of medicated serum of Duhuo Jisheng decoction (DHJS medicated serum, 0.75, 1.5 and 3 g/kg) on rFLS from Freund’s adjuvant-induced arthritis (AIA) rats, the results showed that 20% DHJS medicated serum can induce apoptosis in rFLS (AIA), and the mechanisms are related to regulating Bax, Bcl-2 and Caspase-3 [55].