MAP3K5 and neoplasm: It is noteworthy that Han et al. recently reported that the downregulation of TGFβ2 with adenoviruses delivering short hairpin RNAs (shRNAs) leads to tumor cell death by inducing apoptosis signal-regulating kinase 1 (ASK1) activation and p38 and c-Jun N-terminal kinase (JNK) phosphorylation through an endoplasmic reticulum (ER) stress [33].