Notably, the tumor microenvironment (TME) in GBM displays a T-cell exhaustion signature and pronounced T-cell hypo-responsiveness and TGFβ2 has been implicated as a key contributor to the immunosuppressive landscape of the TME in high-grade gliomas [23,24] especially during the later stages of disease progression [15]. This evidence concerns the gene TGFB2 and central nervous system cancer.