We hypothesize that the observed intratumoral edema as well as PsP among the favorable responders to OT101 may be the result of the inflammatory response of glioma cell death induced by OT101-induced TGFβ2 downregulation perhaps exacerbated by OT101-induced abrogation of the immunosuppressive actions of TGFβ2 in the TME. This evidence concerns the gene TGFB2 and glioma.