NR3C1 and glucocorticoid resistance: In our study, although the treatment non-responder group exhibit elevated inflammation and presence of glucocorticoid resistance in a subset of patients, we have not found significantly higher levels of hsCRP, cortisol and GR resistance compared with treatment responders; this finding would suggest involvement of other pathophysiological mechanisms and aetiological factors associated with their response to treatment, that is important to take into account, considering the heterogeneous nature of MDD.