As representative of simple columnar epithelia, KRT8 is integral to epithelial differentiation.30 It is worth noting that abnormal epithelial‐mesenchymal transition is an important part of the malignant progression.31 Study has revealed that the high expression of KRT8 in gastric cancer is related to the upregulation of EMT pathway and might promote the tumor progression and metastasis.32 However, limited evidence has presented regulation mechanism of KRT8 and EMT signaling pathway in BCa. The gene discussed is KRT8; the disease is gastric cancer.