SNPs of GNPDA2, PGC1α, and LEPR genes contribute to an increased risk of obesity development in Mexican population [28,30–32], and some evidence strongly suggests that obesity-associated polymorphisms are linked with proximal gene regulation, such as enhancers and promoter regions that are differential methylated [43]. Here, GNPDA2 is linked to obesity due to melanocortin 4 receptor deficiency.