GLDC and Hydrocephalus: A direct link between GLDC loss of function and hydrocephalus was confirmed by analysis of mice carrying hypomorphic (GldcGT1) or null (GldcGT2) alleles of the murine homolog, Gldc. A proportion of Gldc mutants die perinatally, owing to neural tube defects (NTDs) resulting from failed neural tube closure (12, 13).