After performing survival analysis, six miRNA-mRNA pairs (hsa-miR-105-5p-GJB2, hsa-miR-522-3p-GJB2, hsa-miR-421-S100A2, hsa-miR-363-3p-SPOCK2, hsa-miR-362-3p-SPOCK2 and hsa-miR-942-5p-SPOCK2) possessed the most potential functions in ovarian cancer and were selected for subsequent expression correlation analysis. This evidence concerns the gene S100A2 and ovarian cancer.