After crossing a transgenic reporter of NF-κB activity Tg(NFkB:EGFP) (Kanther et al., 2011) with Tg(neurod1:RFP), we found that HF feeding significantly increased the number of NF-κB+ EECs (Figure 7K and P), but that this effect could be significantly reduced by treatment with orlistat or the ER stress inhibitor TUDCA (Figure 7L,M and P). This evidence concerns the gene NFKB1 and hydrops fetalis.