In the context of colitis, TSP1 serum levels increased after 7 days of 1% DSS treatment (20.27 ± 11.84 pg/ml in control vs. 37.04 ± 1.21 pg/ml in treated mice) and we sought to analyze the impact of endothelial MT1‐MMP in such release. The gene discussed is MMP14; the disease is colitis.