MMP9 is known to process latent TGFβ into its active form (Yu & Stamenkovic, 2000), and TGFβ was recently shown to be part of the immune‐suppressive TME in colon tumors (Mariathasan et al, 2018; Tauriello et al, 2018). This evidence concerns the gene TGFB1 and colonic neoplasm.