APC and neoplasm: Within the first week of tumor initiation, T‐cell depletion had no effect on the number of cells with increased nuclear and cytoplasmic β‐catenin staining (Appendix Fig S1C and D), suggesting that loss of T cells has no effect on the transformation of tumor initiating cells by recombinase‐mediated Apc gene knockout (Barker et al, 2009).