For example, chronic MnSO4 exposure can activate the hippocampal PI3K/AKT signalling pathway in the rat hippocampus, leading to apoptosis of the central nervous cells, accompanied by enhanced HSPA1A transcription and translation.33 The PI3K inhibitor LY294002 effectively reduces the sensitivity of tumours by down‐regulating the expression of HSPA1A.34 We showed that doubly knocking down HSPA1A and LASP1 resulted in a much more obvious decrease in P‐AKT levels, suggesting a possible strategy to inhibit HNSCC progression. The gene discussed is LASP1; the disease is head and neck squamous cell carcinoma.