In conclusion, ‐‐SEA, ‐α3.7, and ‐α4.2 deletion were the main mutations of α‐thalassemia, while IVS‐II‐654(C → T), CD41‐42(‐TCTT), ‐28(A → G) and CD17(A → T) mutations were the principal mutations of β‐thalassemia in Meizhou. The gene discussed is ITGA2B; the disease is alpha thalassemia spectrum.