von Willebrand disease (VWD) is the most common congenital bleeding disorder caused by quantitative (types 1 and 3) or qualitative (type 2) deficiency of von Willebrand factor (VWF), and its clinical manifestations include mild to severe mucocutaneous bleeding (Swami & Kaur, 2017). This evidence concerns the gene VWF and von Willebrand disease (hereditary or acquired).