In previous reports, RHOA mutations were detected in 50%‐70% of patients with AITL consistent with tour findings.27, 28, 29 Sakata‐Yanagimoto et al recently reported that all cases with the RHOA G17V mutation also had TET2 mutations.27 However, TET2 and DNMT3A mutations were found in nontumor cells of patients with AITL and even in blood cells of healthy individuals.30, 31 On the other hand, RHOA and IDH2 mutations were detected only in tumor cells. This evidence concerns the gene DNMT3A and neoplasm.