As the two‐hit theory of NAFLD claims that inflammation contributes to the progression of NAFLD and more inflammatory infiltration and liver damage were found in NAFLD patients carrying PNPLA3 I148M than those carrying wild‐type genotype,9 we speculated that PNPLA3 I148M is closely related to liver inflammation. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.