EMT led cancer cells to migrate and protected them from hostile environment during the dissemination process.27 The EMT‐associated markers E‐cadherin expression could reflect the ovarian cancer malignancy because E‐cadherin expression was associated with cancer invasion and metastasis.28 By inhibiting E‐cadherin expression and inducing EMT in ovarian cancer cells, the enhanced invasive and metastatic abilities of ovarian cancer cells were achieved.29 In our study, we found that IL‐8 led to an increased protein level of vimentin and a decreased protein level of E‐cadherin. The gene discussed is CXCL8; the disease is cancer.