Our earlier studies demonstrated that l-NAME, a non-selective NOS inhibitor, and 7-nitroindazole (7-NI), a selective inhibitor of nNOS, enhanced DZ-induced, but prevented FNZ-induced memory impairment (acquisition process) in the mEPM (Orzelska et al. 2013) and NOR (Orzelska et al. 2015; Orzelska-Gorka et al. 2016) tests. The gene discussed is NOS1; the disease is memory impairment.