Given the incipient knowledge on OLP etiology and the cytokines participation in OLP, the aim of the present study was to evaluate the gene expression of IFN-γ, IL-17 and IL-33 cytokines, oral microbiome composition and immunohistochemistry analyses with histopathological profile of oral mucosal tissue samples from OLP lesions in order to better diagnosis this disease. Here, IL33 is linked to oral lichen planus.