Further supporting this argument, intestinal epithelia-specific mouse knockout of N-acylphosphatidylethanolamine phospholipase D (N-APE-PLD), the enzyme catalysing conversion of N-acylphosphatidylethanolamines to acyl ethanolamides, results in exacerbation of high fat diet-induced obesity and hepatic steatosis but does not affect glucose metabolism16 whereas adipocyte-specific N-APE-PLD knockout mice exhibit whole body fasted hyperglycemia and hyperinsulinemia, as well as hepatic and skeletal muscle but not adipose insulin resistance17. This evidence concerns the gene NAPEPLD and obesity disorder.