NAPEPLD and obesity due to melanocortin 4 receptor deficiency: Further supporting this argument, intestinal epithelia-specific mouse knockout of N-acylphosphatidylethanolamine phospholipase D (N-APE-PLD), the enzyme catalysing conversion of N-acylphosphatidylethanolamines to acyl ethanolamides, results in exacerbation of high fat diet-induced obesity and hepatic steatosis but does not affect glucose metabolism16 whereas adipocyte-specific N-APE-PLD knockout mice exhibit whole body fasted hyperglycemia and hyperinsulinemia, as well as hepatic and skeletal muscle but not adipose insulin resistance17.