MAGs such as 1-Palmitoylglycerol have been reported26 as positive contributors to Metabolomic Risk Scores discriminating between T2D and control fasting plasma from middle-aged European participants at baseline, implicating higher ‘fasting’ levels of MAGs in normoglycemic individuals as a sign of on-going or impending exhaustion of β-cell function/mass as MAGs enhance glucose-stimulated insulin secretion (GSIS) in the presence of glucose, in rat insulinoma cells, rat islets and human islets27. This evidence concerns the gene INS and pancreatic insulinoma.