MTOR and acute lymphoblastic leukemia: Frequently dysregulated pathways in T-ALL govern NOTCH signalling (60%), the JAK–signal transducer and activator of transcription (STAT) (25%) and phosphatidylinositol 3-kinase (PI3K)–mammalian target of rapamycin (mTOR) (29%) signalling pathways, RAS signalling (14%), and epigenetic regulation (68%)18 (Fig. 2).