In a study by Booth et al.87 investigating the co-operation of Ezh2, Runx1, and FLT3 alterations in T-ALL, BET inhibitors effectively inhibited leukaemic cell growth in vitro and reduced tumour burden in Ezh2–/–Runx1–/–Flt3–ITD mice. Here, RUNX1 is linked to acute lymphoblastic leukemia.