TLX3 and acute lymphoblastic leukemia: NUP214–ABL1 fusions are almost exclusively reported in TLX3-positive and TLX1-positive T-ALL cases (Supplementary Table S1).18,61 A study by Vanden Bempt et al.91 demonstrated the functional significance of constitutive activation of the ABL kinase (following fusion of ABL1 to NUP214) and TLX overexpression in driving T-ALL.